In a medium bowl, combine the buttermilk and hot sauce, if using. Add the chicken tenders to the bowl, ensuring they are fully submerged. Cover and refrigerate for at least 1 hour (or overnight for best flavor).
In another bowl, whisk together the flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper.
Heat a deep skillet or frying pan over medium-high heat and fill it with about an inch of oil. The oil is ready when a drop of batter sizzles in it.
Remove the chicken from the buttermilk, letting the excess drip off. Dredge each tender in the flour mixture, ensuring each piece is evenly coated.
Carefully place the coated chicken tenders in the hot oil, cooking in batches to avoid overcrowding. Fry for 5-7 minutes per side or until golden brown and fully cooked (internal temperature should reach 165°F/75°C).
Once cooked, remove the tenders from the oil and set them on a wire rack or paper towels to drain excess oil.
Notes
Serve with crinkle-cut fries and a tangy dipping sauce. Garnish with fresh parsley.